SHシリーズ
医薬品中の残留溶媒分析④
Residual Solvent, USP 467 Class 1
| 化合物 | SN 比 | 相対標準偏差 (n=6) |
|---|---|---|
| 1. 1,1-Dichloroethane | 320 | 2.8 |
| 2. 1,1,1-Trichloroethane | 220 | 2.3 |
| 3. Carbon tetrachloride | 20 | 2.9 |
| 4. Benzene | 170 | 2.5 |
| 5. 1,2-Dichloroethane | 60 | 3.4 |
GC 分析条件
| Model | Nexis GC-2030 | Linear Velocity | 35 cm/sec |
|---|---|---|---|
| Detector | FID-2030 | Detector Temperature | 250℃ |
| Headspace Sampler | HS-20 | FID H2 Flow Rate | 40 mL/min |
| Column | SH-I-624 Sil MS (0.32 mm I.D.×30 m, d.f. = 1.8 μm) | FID Make up Flow Rate | 30 mL/min (He) |
| Column Temperature | 40℃ (20 min) ‒ 10℃/min ‒ 240℃ (20 min) Total 60 min | FID Air Flow Rate | 400 mL/min |
| Injection Mode | Split 1：5 | Injection Volume | 1 mL |
| Carrier Gas Controller | 線速度 (He) |
HS-20 分析条件
| Oven Temperature | 80℃ | Vial Volume | 20 mL | Vial Pressure | 75 kPa |
|---|---|---|---|---|---|
| Sample Line Temperature | 110℃ | Vial Heat-retention Time | 60 min | Loading Time | 1 min |
| Transfer Line Temperature | 120℃ | Vial Pressurization Time | 1 min | Needle Flush Time | 5 min |
| Vial Stirring | Off |
【出典】株式会社島津製作所SHシリーズアプリデータ集 (株式会社島津ジーエルシー発行)
