SHシリーズ
医薬品中の残留溶媒分析①
Residual Solvent
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Peak tR (min) Conc.
(μg/mL)1. Acetonitrile 2.056 410 2. Dichloromethane 2.185 600 3. trans-1,2-Dichloroethene 2.431 940 4. Hexane 2.707 290 5. Nitromethane 3.497 50 6. cis-1,2-Dichloroethene 3.581 940 7. Tetrahydrofuran 3.948 690 8. Chloroform 4.125 60 9. 1,1,1-Trichloroethane 4.329 1,500 10. Cyclohexane 4.427 3,880 -
Peak tR (min) Conc.
(μg/mL)11. 2-Methoxyethanol 5.079 50 12. Trichloroethene 6.095 80 13. Methylcyclohexane 6.373 1,180 14. 1,4-Dioxane 6.554 380 15. 2-Ethoxyethanol 6.982 160 16. Pyridine 7.439 200 17. Toluene 7.587 890 18. Ethylene glycol 7.748 620 19. 2-Hexanone 8.260 50 20. Dimethylformamide 8.597 880 -
Peak tR (min) Conc.
(μg/mL)21. Chlorobenzene 8.882 360 22. Ethylbenzene 8.985 368 23. p-Xylene 9.096 304 24. m-Xylene 9.096 1,302 25. o-Xylene 9.412 196 26. N,N-Dimethylacetamide 9.654 1,090 27. 1-Methyl-2-pyrrolidone 11.466 530 28. 1,2,3,4-Tetrahydronaphthalene 12.116 100 29. Sulfolane 13.266 160
| Column | SH-I-624Sil MS, 20m, 0.18mm ID, 1.00μm (P/N: 227-36075-01) | Flow Rate | 1.35 mL/min |
|---|---|---|---|
| Inj. Vol. | 0.5 μL split (split ratio 50:1) | Linear Velocity | 45 cm/sec |
| Liner | 5mm split | Dead Time | 0.74 min @ 40℃ |
| Inj. Temp. | 250℃ | Detector | FID @ 250℃ |
| Oven Temp. | 40℃ (hold 5 min) to 260℃ @ 50℃/min | Data Rate | 50 Hz |
| Carrier Gas | He, constant flow |
【出典】株式会社島津製作所SHシリーズアプリデータ集 (株式会社島津ジーエルシー発行)
