医薬品中の残留溶媒分析①

Residual Solvent

  • 医薬GC残留溶媒
  • GLC Application

医薬品中の残留溶媒分析

  • Peak tR (min) Conc.
    (μg/mL)
    1. Acetonitrile 2.056 410
    2. Dichloromethane 2.185 600
    3. trans-1,2-Dichloroethene 2.431 940
    4. Hexane 2.707 290
    5. Nitromethane 3.497 50
    6. cis-1,2-Dichloroethene 3.581 940
    7. Tetrahydrofuran 3.948 690
    8. Chloroform 4.125 60
    9. 1,1,1-Trichloroethane 4.329 1,500
    10. Cyclohexane 4.427 3,880
  • Peak tR (min) Conc.
    (μg/mL)
    11. 2-Methoxyethanol 5.079 50
    12. Trichloroethene 6.095 80
    13. Methylcyclohexane 6.373 1,180
    14. 1,4-Dioxane 6.554 380
    15. 2-Ethoxyethanol 6.982 160
    16. Pyridine 7.439 200
    17. Toluene 7.587 890
    18. Ethylene glycol 7.748 620
    19. 2-Hexanone 8.260 50
    20. Dimethylformamide 8.597 880
  • Peak tR (min) Conc.
    (μg/mL)
    21. Chlorobenzene 8.882 360
    22. Ethylbenzene 8.985 368
    23. p-Xylene 9.096 304
    24. m-Xylene 9.096 1,302
    25. o-Xylene 9.412 196
    26. N,N-Dimethylacetamide 9.654 1,090
    27. 1-Methyl-2-pyrrolidone 11.466 530
    28. 1,2,3,4-Tetrahydronaphthalene 12.116 100
    29. Sulfolane 13.266 160
Column SH-I-624Sil MS, 20m, 0.18mm ID, 1.00μm (P/N: 227-36075-01) Flow Rate 1.35 mL/min
Inj. Vol. 0.5 μL split (split ratio 50:1) Linear Velocity 45 cm/sec
Liner 5mm split Dead Time 0.74 min @ 40℃
Inj. Temp. 250℃ Detector FID @ 250℃
Oven Temp. 40℃ (hold 5 min) to 260℃ @ 50℃/min Data Rate 50 Hz
Carrier Gas He, constant flow

【出典】株式会社島津製作所SHシリーズアプリデータ集 (株式会社島津ジーエルシー発行)

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