遺伝毒性不純物分析 メシラート、ベシラート、トシラート

    Genotoxic Impurities; Mesylate, Besylate, Tosylate

    • 医薬GCMS薬物・毒物
    • GLC Application

    遺伝毒性不純物分析 メシラート、ベシラート、トシラート

    • Peaks tR (min) Ions Monitored (m/z)
      1. Methyl methanesulfonate (MMS) 5.043 79, 80, 95
      2. Isopropyl methanesulfonate (iPMS) 6.010 59, 79, 123
      3. Diethyl sulfate (DES) 6.357 111, 125, 139
      4. di-isopropyl sulfate (DPS) 6.970 45, 87, 167
      5. dibutyl sulfate (DBS) 9.260 29, 41, 56
      6. Methyl benzenesulfonate (MBS) 9.463 77, 141, 172
      7. Ethyl benzenesulfonate (EBS) 9.883 77, 141, 186
    • Peaks tR (min) Ions Monitored (m/z)
      8. Methyl toluenesulfonate (MTS) 10.337 91, 155, 186
      9. Ethyl toluenesulfonate (ETS) 10.713 91, 155, 200
      10. n-propyl toluenesulfonate (nPTS) 10.827 91, 155, 172
      11. n-butyl benzenesulfonate (nBBS) 11.07 77, 141, 159
      12. isopropyl p-toluenesulfonate (iPTS) 11.240 91, 155, 172
      13. p-toluenesulfonic acid n-butyl ester (nBTS) 11.823 91, 155, 173
    Column SH-I-624Sil MS, 20m, 0.18mm ID, 1.00μm (P/N: 227-36075-01) Detector MS
    Diluent 90:10 acetonitrile:water Mode SIM
    Conc. 500 ng/mL Transfer Line Temp. 280℃
    Inj. Vol. 1 μL splitless (hold 0.5 min) Analyzer Type Quadrupole
    Liner 3.5mm Single Gooseneck Liner with wool placed 3cm from top (middle) Source Temp. 280℃
    Inj. Temp. 220℃ Solvent Delay Time 4 min
    Purge Flow 3 mL/min Ionization Mode EI
    Oven Temp. 80℃ (hold 2 min) to 300℃ @ 20℃/min (hold 5 min) Instrument Shimadzu 2010 GC & QP2010+ MS
    Carrier Gas He, constant flow Acknowledgement In collaboration with Merck and Company
    Linear Velocity 45 cm/sec

    【出典】株式会社島津製作所SHシリーズアプリデータ集（株式会社島津ジーエルシー発行）

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